You and a friend are enjoying an

You and a friend are enjoying an easy run in the park, taking the time to catch up on the previous weekend’s activities. Your friend has just come back from a family reunion. “It was kind of depressing, really,” your friend says. “We went to this great lake house my aunt and uncle own. They have a ski boat and a jet ski. It’s awesome.” “Doesn’t sound like much to be depressed about,” you say. “What was the problem?” “It was my uncle. I mean, he was always the life of the party whenever we’d visit. He’d be out there driving the boat or skiing himself. But this time all he did was sit in a chair.” “What’s up with that? I mean, why the change if he used to be so active?” you ask. “I’m not exactly sure. My mom said he was diagnosed with kidney failure a few months ago, but he’s getting treatment. I guess he’s really tired, ’cause he doesn’t move around. And his ankles are really swollen. Not sure what that’s from, but I keep wondering if the swelling would go down if he just moved around some. I hate seeing him like this. I wish I could understand what’s going on.” Questions: 1. What are the three main causes of edema? 2. What is colloid osmotic pressure? Explain how this would be affected by a loss of albumin in the urine. 3. What is capillary filtration? Explain how an accumulation of blood in the veins and capillaries would affect pressure and therefore filtration. 4. What are the effects of inactivity on venous return and the ultimate effects on capillary filtration? 5. What is the skeletal muscle pump and explain how it helps facilitate blood return to the heart?

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